Why Bioavailability Is Vital in Clinical Studies
According to National Cancer Institute Bioavailability is the “ability of a drug or other substance to be absorbed and used by the body. Orally bioavailable means that a drug or other substance that is taken by mouth can be absorbed and used by the body." Evaluating from the nutritional perspective, bioavailability implies that the digestive system can extract nutrients from the product in a form that can easily absorb into the bloodstream. Importance of Bioavailability Bioavailability is crucial from the nutritional perspective as our body can have more available nutrients when the supplements are in a liquid form. The majority of the nutrients are in pill form. According to the Physicians Desk Reference 85 to 90 percent of the nutrients in the liquid supplements are absorbed within a time frame of 22 to 30 seconds. In case the same is in the form of a pill, then it takes a minimum amount of 10 to 20 percent of nutrients area that is absorbed in the body. Reasons for Bioavailability studies There are multiple reasons because of which bioavailability is considered as an essential part of the clinical trial process and studied. The data obtained helps too: * Offer practical information on the potential health effects of contamination * Helps to modify defaults by using site specific data * Helps to change proposed cleanup levels and saves time and money to reach the accepted levels * Helps to prioritize sites for subsequent evaluation How to measure bioavailability? There are various ways that can be used to evaluate bioavailability. A Site specific analysis provides vital information that can impact a risk assessment. In soil, a contaminant bioavailability can be measured in multiple ways that include the following: * Extraction using acids and bases * Extraction using biological fluids * In vitro assays using bacterial systems * In vivo assays using aquatic mammals and organisms * Statistical estimation procedures Estimating the bioavailability has become an essential tool to reduce the new formulation developed by a pharmaceutical company. Today clinical research organizations carry on bioavailability studies to provide meaningful clinical pharmacokinetic data related to removal, dissemination, the effects of nutrients on absorption of the drug, linearity in the pharmacokinetics of the active moieties and inactive moieties, dose proportionality and so on. Bioavailability data can also offer data directly about the drug substance properties prior to its entry into the systemic circulation, for instance permeability and the impact of pre-systemic enzymes and transporters. Read More About: biometrics companies, regulatory services